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One in seven Americans suffered it. Appendicitis. What is it?

It's 10 pm. Severe pain in your belly. surgical treatment. It happens in elderly
You are in ER. Previous day you had a patients. The patients may come to the
nice party with your friends. Then pain hospital with a lump or a mass in the
started around your umbilicus (navel). right lower abdomen looking like
You thought first: aha, probably you ate tumor.Diagnostic problem with
something bad, it will go away. But it appendicitis is that some other
doesn't. You have vomited once and lost conditions may mimic it.Abdominal cavity
appetite. Pain did not improve but is packed with different organs. Other
worsened. After a day of suffering you sources could cause pain in right lower
decided to visit the hospital. Long taxi quadrant. Females may have ovarian
trip. Pain is shooting every time the car torsion or tuboovarian abscess or
bumps into a pot. Nurses ask you bunch of extrauterine pregnancy (this is why
questions and place in an available room. doctors persistently ask: when was your
There is a confused 90 something years last menstrual period? Are you taking
old women in the neighbor room. She contraceptive hormones? Did you have
mumbles something incomprehensibly. The vaginal bleeding?), etc. They also check
woman has come from a nursing home. She your chorionic hormone, trying to find if
suffers Alzheimer disease and yells every you are pregnant.Scrupulous doctor asks
night for the past 7 years. She has your permission to perform rectal exam.
history of multiple medical problems. Many people refuses to do it. I can
They brought her in the ER after she understand that. Who would like that
developed fever. Nurses draw your blood. somebody sticks fingers into his ass. I
You pain is getting gradually worse. wouldn't. But the rectal exam gives a lot
Change your position, pull your legs. of information. Rectum - is the part of
Pain doesn't go away. When the ... doctor gut that is closest to the back orifice.
comes? At last ER physician sees you. He Back orifice is named anus in Latin or
writes H+P and ER orders. A stretcher is anal canal. Surgeons say that there are
rolled in. They take you to a radiology only two contra-indications for avoiding
department and put into a big machine rectal exam: 1. patient does not have
looking like a gate. Everybody leaves you anus 2. Surgeon does not have
and the machine drives you into the big fingers.Rectal exam in appendicitis is
metal doughnut. They bring you back into usually unremarkable. Maybe you can cause
the ER.Surgical intern comes. He did not pain by palpating the side wall of the
rest since 5 AM. He asks bunch of the rectum that is close to the appendix. But
same questions again and pokes your the rectal exam allows to distinguish
belly. A tired resident comes. He pokes other disorders. During the rectal exam
your belly again. You still wait, become you may palpate hemorrhoids, uterus,
bored, complain on delay, call your nodules in prostate or enlarged prostate,
relatives. It's already 2 AM. At last the you may feel fluid in lower part of
resident discuss your symptoms with peritoneal cavity, etc. You may see blood
attending over the phone. He tells you on the finger telling you about internal
that you have appendicitis and CT scan bleeding. You may check the stool for
confirmed it. History and physicals are small amount of blood (named fecal occult
written. Admission orders are written. blood test - FOBT - or Guaiac test by the
Pre-op orders are written. Antibiotics name of the dye that turns blue in the
are prescribed. IV fluid is running 80 ml presence of blood. At last rectal exam
an hour. You sign consent for operation. may help in dis-impaction of rectum. That
Transporting guys take you upstairs - is when hard stool causes bowel
depending on severity of your symptoms - obstruction.Usually a rectal exam is more
straight to or to the floor. Attending or less normal. But every surgeon will
will operate you first thing in the tell you a war story about how once in
morning.Classically appendicitis starts while, once in five years he found
as a pain that began in the periumbilical something significant on rectal exam,
region (around navel - you belly pot). something that every other doctor missed.
Then pain moves to the right lower Just by putting the finger into the butt.
quadrant of the abdomen. Nausea and I saw how a surgeon put a finger into an
vomiting often present after the onset of old, demented women and pulled out a
the pain. Classically, patient has low pessarium. It was an apple-size pink
grade fever (this means around 37-38 C or plastic membrane , that should go into
101-102 F), positive psoas sign (you vagina, but somebody (at home?) put it
stretch your leg and this movement (by mistake?) into the rectum of that
increases your pain), positive Rovsing woman. You really need to push hard to
sign (Doctor pokes in your left lower get such big object into the anus. The
quadrant of the abdomen, and you fill the poor lady suffered bowel obstruction for
pain in you right lower quadrant), a week and would probably die if it
Leukocytosis. Leukocytes are the white stayed long enough.OK, lets return to
blood cells - WBC. Usually there are appendicitis. So, doctors will check you
around 4000-9000 white cells per micro White Blood Cell Count Any infection or
liter of you blood. When you have inflammation may cause this count to be
inflammation in you body the count goes abnormally high. It is not specific for
up.Your pain during appendicitis appendicitis, but it confirms other
classically localizes in Mc Burney's findings.Next, doctors check Urinalysis -
point. That is one third between your microscopic examination of the urine.
umbilicus and anterior superior iliac That detects red blood cells, white blood
spine (this is the bony point that is cells and bacteria in the urine. When
sticking most prominently from your there is inflammation or stones in the
pelvis - you can palpate it yourself on kidneys or bladder, the urinalysis is
the side of your belly). For confirmation abnormal. A normal urinalysis is more
a doctor also may try to elicit obturator characteristic to appendicitis.Next they
sign - he will ask you to bend you knee try to image what is going on in your
and bring your heel to your groin - this belly. An abdominal x-ray may detect the
manoeuver increases the pain during fecalith as the cause of appendicitis
appendicitis. Similar test is the raising (5%). Free air due to perforation can
of the leg while you lie on the might be seen on the plain film.A barium
stretcher. That movement also increases enema may be used. It is an x-ray test
your pain.Appendicitis is the where liquid contrast is used from the
inflammation of appendix supposedly due anus to fill the colon. Sometimes it show
to narrowing of this lumen. That an impression on the colon in the area of
narrowing may be caused by hyperplasia of inflamed appendix. Barium enema also can
appendix (means too big growth, exclude other intestinal problems that
overgrowth of the tissue) . That variant mimic appendicitis.Ultrasound shows an
happens in children mostly. Another enlarged appendix or an abscess.
variant - is fecalith (small stony fecal Ultrasound is painless, but the appendix
material) that impacts into the appendix can be seen in only half of patients.
lumen. That is seen in young adults Ultrasound also is helpful in excluding
mostly.Appendix itself is a small part of the problems with ovaries, fallopian
gut . It is pencil-size sticking out gut. tubes and uterus. Ultrasound machine
Gut is a continuos tube. Mouth is entry. usually looks like a small thumb on
Anus is exit. Appendix sticks out from wheels that they bring into your room.
the wall and ends blindly. It has only Technician puts gelly on and drives the
one entrance. Appendix is attached to the probe over you belly.Often they go
Caecum (part of gut - literally means straight to CT Scan (computer
blind colon in Latin). Appendix of tomography). Especially if the patient is
ruminating animals (animals that chew not pregnant. CT scan gives relatively
grass, like cow) is very long and big. high irradiation of your body by x-rays.
Appendix in humans is reduced to the However benefits of prompt diagnose of
pencil-size. However it doesn't appendicitis outweigh the risk of
disappear. There is a theory that radiation. CT scan gives slicing images
appendix plays role in immune response. of your body.What do they look for? As
The walls of appendix are actually filled any inflamation causes edema, the wall of
with lymphatic tissue containing the appendix will be thickened. This is
lymphocytes (those are subtype of White actually a defensive mechanism - by edema
Blood Cells). Lymphatics is responsible the organism try to wall of, to seal off
for immunity.The removal of appendix the area of infection and inflamation.But
doesn't really change immunity it is useful for us because we can surely
significantly. Nonetheless, it is not say there is an inflammation. The same
something redundant. Unless it is goes for ultrasound.CT scan is expensive
inflamed there is no good reason to - around 1000 dollars in an American
remove it .Now, acute appendicitis is the hospital, though 40 dollars in Russia.If
acute inflammation of appendix. Suffix the CT scan is taken during the night, CT
"-itis" means inflammation in Latin. image may be send to Australia Russia or
Appendicitis is also the most common India.An American radiologist is paid
cause of acute abdomen. Acute abdomen in around 40 dollars to read just an X-ray
surgery is a condition in abdomen that film. I guess he gets more for reading
requires urgent actions, usually the CT scan. It is only 5 dollars in
surgical.To diagnose appendicitis you India. This is why even such clinics as
need to have right lower quadrant Harvard and Yale adopt this model of work
pain.The pain should be present together - they send the CT scans to the cheap
with either appropriate history (all labor abroad. Especially during the
those classical signs and lack of night. Half an hour later the fax from
appetite) or Leukocytosis (increase in Australia arrives. "Inflammatory
white blood cells in the blood).Patients pericecal mass in the right iliac fossa
often ask questions: Can I avoid surgery? consistent with the diagnosis of severe
Can you treat me with antibiotics alone? acute appendicitis." Any doctor can read
You told me that it is possible to treat an x-ray film or CT scan. Radiologists
the appendicitis with antibiotics alone. are doctors who specialize in the reading
Please, I do not want surgery, my mother of the films. They may find what was
(father, brother, fiancee) said that I missed by others.At this point diagnosis
can avoid surgery.The answer is: you can is usually clear. In cases if it is not,
try to avoid it probably, but the odds of there is Laparoscopy. Laparoscopy is a
death are much higher if you treat surgical procedure. Small fiberoptic tube
appendicitis without surgery. Untreated with a camera is inserted into the
appendicitis may lead to perforation in abdomen through a small puncture in
less than a day. Sun rises. Sun sets. abdominal wall.Yet there is no test that
Appendix bursts. So, the prompt surgical will diagnose appendicitis with 100%
intervention is the main solution. On certainty.The position of the appendix
occasion, the surgeon may even find a may vary. If it is longer than normal,
normal-appearing appendix and no other appendix may go deep down into the
problem explaining the symptoms. He may pelvis. It also may move behind the colon
remove the appendix anyway because it is (called a retro-caecal appendix). From
better to remove a normal-appearing one hand it is better because
appendix than to miss mild case of retro-caecal appendix has less chances to
appendicitis.To cool down the infection burst into peritoneal cavity, from the
before surgery doctors use antibiotics. other it is difficult to diagnose and it
Antibiotics may convert acute is difficult to approach surgically.
appendicitis into more chronic type. Inflammation of other organs, for
However the removal of the appendix is example, female pelvic organs, may
the choice.With modern technology it resemble inflammation of the appendix.
becomes much easier to distinguish Pregnant women may have appendix pushed
appendicitis and other causes of pain in up in abdomen by the enlarged uterus.
right lower quadrant. Yet there is no Athletic young adults may tolerate more
100% proof diagnostics. Sometime doctors pain and may have not so obvious symptoms
treat with antibiotics alone, when they of appendicitis. Old patients may have
are not sure. Though, modern CT-scan vague symptoms as well.Other inflammatory
shows appendicitis almost close to problems may mimic appendicitis. Surgeons
100%.What would happen if you miss the often observe patients with suspected
appendicitis and appendix bursts? You appendicitis for a period of time to see
will get one of the most dreaded surgical if the problem will resolve or suggest
complication - peritonitis. Again, appendicitis more strongly versus another
"-itis" equals inflammation. Peritoneum condition. Conditions that mimic
means the peritoneal cavity.It is appendicitis are:1) Meckel's
difficult to describe the shape of the diverticulitis. 2) Pelvic inflammatory
peritoneal cavity . That shape is very disease -infection of tube and ovary. It
complex. Simple explanation: peritoneal is treated with antibiotics alone 3)
cavity is like a closed bag. It is Fluids from the right upper abdomen may
completely closed in malesFemale have drip into the lower abdomen and cause
small holes in the peritoneum. Oocytes inflammation resembling appendicitis.
(future babies) go from ovaries first to Then, for example, patient has
peritoneal cavity. The holes in the gallbladder disease or liver abscess, but
peritoneum allow oocyte to go into all symptoms suggest acute appendicitis.
Fallopian tubes. Fallopian tubes lead 4) Diverticulitis that occur on the right
into the uterus (womb in English or side. 5) Inflammation of right kidney. 6)
hyster in Latin or uterus in Greek). Crohn's disease or ulcerative colitis 7)
Organs that are covered by peritoneal Yersinia enterocolitica infection - the
cavity linings are named bacteria that comes form certain food -
intra-peritoneal. There are also like unpasteurized milk. - may cause
melo-peritoneal, extra-peritoneal or appendicitis 8) passing kidney stone 9)
retro-peritoneal organs that covered ectopic pregnancy 10) ovarian cyst
partially or not covered at all. It looks rupture. And so on. There are some other
like the main function of peritoneum conditions.Appendectomy is performed
(peritoneal cavity) is to give some urgently usually. Thomeo is Latin for
lubrication to your guts. Though there dissect or cut. Lapar - is abdomen
are other functions as well.Now, take a (belly) in medical Latin. Laparotomy is
plastic bag, pour a little bit of water opening of belly. Appendectomy is cutting
or oil into it and seal. Put one hand on of appendix. Laparoscopy is looking (by
one side of the bag, another hand - on scope) into belly. Antibiotics almost
another side of the bag and rub against always are given prior to surgery as soon
each other. You can see your hands slide as appendicitis is suspected.Few patients
easily. This is the idea of peritoneum - have mild "confined appendicitis"
you bowels slide easily against each localized to a small area. These patients
other even when they are stretched by may improve during several days of
food and when they are pushing the observation when treated with antibiotics
digested food down. When a bowel is alone. Doctors may or may not removed the
punctured (perforated), the content of appendix later. Chances are you are not
the bowel will go into the peritoneal one of this patients.If a person has not
cavity. Colon (lower, bigger bowl) has seen doctor for many days while
the fecal material. Fecal material appendicitis ruptured (yeah, sometime
consists of bacteria on 2/3 (yeah, there happens; there are some tough guys), an
are so many of them). Now, that small abscess may form, and the perforation may
puncture in one part of the gut will close. Initially it can be treated with
cause spillage of the bacteria all around antibiotics; however, that will require
that closed bag of peritoneum.Guts on drainage later. A drain is guided under
inside have several mechanisms protecting ultrasound or CT scan and appendix is
from bacteria. Peritoneal cavity doesn't' removed after the abscess resolves.In
have such a protection.Small puncture in modern days surgeons offer laparoscopic
one part of gut will cause all of you appendectomy. They insert laparoscope (it
guts be inflamed on outside non-protected is like a small telescope with a video
side (for the gut it is outside, but for camera) and remove appendix with special
the peritoneal cavity it is the inside). instruments through small puncture
This is the peritonitis (diffuse). This wounds.If you had this type of surgery,
what the surgeons are afraid of. Look at you will probably have four 1-cm size
you. You belly is like half of you body. scars and you will go home in one or two
So it is like half of you body is days.But if your case is complicated or
severely inflamed. Eventually it may lead there is just no laparoscopy in the
to sepsis, a condition in which bacteria hospital, they will do classical
enter the blood and infect other parts of appendectomy. Surgeon cuts 10-cm incision
the body. This is life-threatening in the area of the appendix. Appendix is
complication.Sometime inflammation stays removed form the right lower abdomen or
local and seals off forming an abscess. where it is. Area is checked for other
Abscess is the walled off accumulation of problems. In the case of abscess the
pus. Pus is the mixture of dead and alive purulent stuff will be drained with
bacteria, dead white blood cells rubber tubes through the skin. With that
(leukocytes; leukos = white, cyte = cell) kind of surgery you will probably stay
that fought the infection and honorably for four to seven days. Antibiotics will
died, and dead tissue, that was digested help to resolve the abscess.This is why
partially by bacteria and partially by you sign the consent: "laparoscopic
the stuff from leukocytes. Inflamed appendectomy, possible conversion to an
peritoneum (the lining of the peritoneal open appendectomy".The most common
cavity is also named peritoneum) easily complication of appendectomy is wound
adhere to each other and may seal of the infection. If it is severe, the surgeon
infection - there will be local will postpone incision closure for
peritonitis. Any adherence may cause several days.Ok, now you have those four
problems in the future - guts do not small scars or one big scar, you go home
slide easily anymore and food or stool and visit that party that you
sticks. Blockage of the intestine may missed.Aleksandr Kavokin, MD1994
occur in acute appendicitis as well. This Russia,PhD1997 Russia - Immunology and
is partially responsible for the nausea Allergy, postdoc at Cancer Center at Med
and vomiting. Sometimes, when antibiotics U of South Carolina, postdoc at Yale -
are used, appendicitis goes away without Cardiology, Molecular Medicine.




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